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| 1348 |
| | | The Black Death, making its way through Europe, is described in vivid detail by Boccaccio who sees its devastating effect in Florence | |
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| c. 1349 |
| | | Boccaccio begins his Decameron, supposedly the stories told by young Florentine men and women sheltering from the Black Death | |
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| 1350 |
| | | Boccaccio, visiting Petrarch in Florence, is inspired to devote himself to the pursuit of classical studies | |
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| 1378 |
| | | John Hawkwood, a condottiere in command of the White Company, is appointed captain general of Florence | |
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| 1406 |
| | | Pisa is captured by Florence, to be followed a few years later by the purchase of the seaport of Livorno | |
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| 1411 |
| | | The linen drapers of Florence commission a statue of St Mark from Donatello, who carves for Orsanmichele the first free-standing Renaissance sculpture | |
|  | Donatello, St George
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| 1418 |
| | | A competition is launched for an architect to construct a dome above Florence's cathedral, and is won by Brunelleschi | |
|  | Florence, the cathedral dome
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| 1423 |
| | | Masaccio paints some of the frescoes in the chapel of a Florentine silk merchant, Felice Brancacci, in Santa Maria del Carmine | |
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| 1430 |
| | | Work begins in Florence on Brunelleschi's Pazzi chapel, which encapsulates in miniature the new ideals of Renaissance architecture | |
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| 1439 |
| | | Florence acquires first-hand experience of Greek culture when Greek Orthodox priests join in a debate on theology, in particular the question of Filioque | |
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